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Predicted treatability was compared both to predicted tumor coverage and to the clinically treated tumor volume. The intended and simulated volumes and positions of ablated tissues were compared. Predicted treatability was less than coverage by 52% (range 31-78%) of the tumor volume. Predicted and clinical treatability differed by 9% (range 1-25%) of tumor volume. Ablated tissue volume and position varied with beam path length through tissue. Tumor coverage overestimated patient suitability for MRgHIFU therapy. Employing patient-specifi