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Nowadays, there have been attempts to use phytochemicals in fruits to reduce the risk of suffering a given sickness. In this work, we studied the potential effects of mango (cultivar "Nam Dok Mai" and banana (cultivar "Khai" to attenuate DNA oxidative damage in MCF-10A cells induced by 4-hydroxyestradiol (4-OHE2 ). The effects of mango extract (MNE) and banana extract (BKE) were comparable with three carotenoid compounds, β-carotene, lycopene, and lutein. The oxidative-induced DNA damage was evaluated by 8-hydroxy-2-deoxyguanosine (8