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BACKGROUND Coccidioides spp are dimorphic fungi endemic to parts of the United States, Mexico, Central, and South America. Infection can cause a range of disease from self-limited acute pneumonia to severe, disseminated disease. METHODS We performed a retrospective chart review of medical records of cases of culture-proven acute coccidioidomycosis at the University of California San Diego between April 1, 2015 and December 31, 2019 and described the demographics, risk factors, and outcomes of these cases. RESULTS Over the stu