https://www.selleckchem.com/pr....oducts/gsk1016790a.h
The entry of blood-borne molecules into the brain is restricted by the blood-brain barrier (BB. Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive Tie2-Cre showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor-related protein 1 (LRP1). Taking advantage of conditional Slco1c1-CreERT2 s
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