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Two-week administration of substances with antidepressant properties, imipramine (7 mg/kg/day) or thiamine (vitamin B1; 200 mg/kg/day) ameliorated the majority of the modFST-induced modifications. Therefore, enhanced discovering of negative memories is connected with pro-inflammatory modifications that should be considered for optimizing pharmacotherapy of depression involving improved discovering of aversive thoughts. Methylglyoxal (MGO) is an endogenous poisonous compound that plays a vital ro
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