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To figure out the impact of national health insurance program and treatment modalities on the clinical outcomes of patients with retinoblastoma. Retrospective cohort study. Enrolled patients were classified into three groups according to the time period in which their initial diagnosis was performed patients diagnosed before 1995 (group 1), patients diagnosed in the time period 1995-2010 (group 2), patients diagnosed after 2010 (group 3). Comparison was made of clinical features including presenting signs, tumor spreading, and treatment
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