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CONCLUSION The CYP2D6 and APOE genotypes may modulate the effectiveness of donepezil on cognitive and functional status. © 2020 Japanese Psychogeriatric Society.Increasing direct human pressures on the marine environment, coupled with climate-driven changes, is a concern to marine ecosystems globally. This requires the development and monitoring of ecosystem indicators for effective management and adaptation planning. Plankton lifeforms (broad functional groups) are sensitive indicators of marine environmental change and can provi