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This study aims to evaluate the ability of tantalum-coated titanium to improve human gingival fibroblasts' adhesion, viability, proliferation, migration performance, and the potential molecular mechanisms. Titanium plates were divided into two groups (1) no coating (Ti, control), (2) Tantalum-coated titanium (Ta-coated Ti). All samples were characterized by scanning electronic microscopy, surface roughness, and hydrophilicity. Fibroblasts' performance were analyzed by attached cell number at 1 h, 4 h, and 24 h, morphology at 1 h and 4 h, v