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The GDS score and disease duration were independent variables of PDQ-39 in PDD patients. The determinants of QoL in PD-NC, PD-MCI and PDD patients were heterogeneous. Motor function was considered to be the most crucial determinant for QoL in PD-NC, while depression was indicated to be the most vital determinant for PD-MCI and PDD. For QoL improvement, clinicians might need to focus more on motor function in PD-NC patients and on depression in PD-MCI and PDD patients. The determinants of QoL in PD-NC, PD-MCI and PDD patients were heteroge
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