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RESULTS Compared with controls, acute LBP individuals had higher TNF and CRP but lower adiponectin. In LBP, unrecovered individuals had higher TNF at both time points, but lower CRP at baseline and leptin at six months. Although combined low CRP, high TNF, and depressive symptoms at baseline predicted poor recovery, the primary adipokines leptin, resistin, visfatin, and adiponectin did not. CONCLUSIONS Primary adipokines did not add to the prediction of poor LBP outcome that has been identified for the combination of low CRP, high TNF, an