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By choosing optimal flow rates during synthesis an encapsulation efficiency of 75 ± 24% was achieved. Finally, we show that this approach achieves significantly enhanced solubility of celastrol in the aqueous phase and, crucially, reduced cellular toxicity. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Photosensitizer-polyoxometalate (PS-POM) dyads are promising systems for light-induced energy conversion, e.g. "solar" hydrogen generation. PS-POM dyads often feature short-lived photoinduced charge-separated states (CSS), the life