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With respect, mastering and hippocampus-dependent memory had been analyzed. Male BALB/C mice received FICZ, CH223191, and XAV-939 in just one dosage of 100 μg/kg, 1 mg/kg, and 5 mg/kg of weight correspondingly via intraperitoneal (IP) shot. qRT-PCR for gene analyses and necessary protein assay in the seventh and 28th times had been performed. To assess the hippocampal centered memory, additionally they underwent contextual fear conditioning from the 28th time after tre