https://www.selleckchem.com/pr....oducts/homoharringto
Low metformin concentration was found in the brain at ~20% of the plasma level. Furthermore, gender difference in steady-state metformin bio-distribution was observed. Our study established steady-state metformin levels in plasma, liver, muscle, kidney, and brain of normoglycemic mice treated with a clinically relevant dose, providing insight into future metformin preclinical studies for potential clinical translation.In most cases, multiple sclerosis (MS) patients reduce physical activity with disease progression and many pat
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