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n support of our findings. Toxicology and Safety, Quality Traditional Medicine. Toxicology and Safety, Quality Traditional Medicine. Cariniana rubra Gardner ex Miers (Lecythidaceae), is a native and endemic tree in Brazil, whose inner stem bark decoction preparation is used in folk medicine to treat various inflammatory disorders. Previous scientific reports confirmed its popular use as an anti-inflammatory, without, however, evaluating its action mechanisms. The objective of this study was to determine the cytotoxicity and anti-infl