https://www.selleckchem.com/pr....oducts/cfi-400945.ht
Randomized controlled trials have been unable to detect a cardiovascular benefit of continuous positive airway pressure (CPAP) in unselected patients with obstructive sleep apnea (OSA). We hypothesize that deleterious cardiovascular outcomes are concentrated in a subgroup of patients with heightened apnea/hypopnea-related pulse rate response. We measured the pulse rate response to apneas/hypopneas (∆HR) in the Multi-Ethnic Study of Atherosclerosis (MESA, N=1395) and the Sleep Heart Health Study (SHHS, N=4575). MESA data were used to
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