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In conclusion, we have identified an lncRNA Gm15622-miR-742-3p-SREBP-1c regulatory circuit associated with NAFLD in mice, a finding that significantly advances our insight into how lipid metabolism and accumulation are altered in this metabolic disorder. Our results also suggest that Gm15622 may be a potential therapeutic target for managing NAFLD. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.The developing nervous system is remarkably sensitive to environmental signals, including disruptive to