https://www.selleckchem.com/products/GDC-0449.html
In B cell acute lymphocytic leukemia (B-ALL), B cells are blocked mainly at the pro/pre-B phase, making them poorly responsive to imatinib. We aimed to investigate whether it was possible to promote pro/pre-B cell maturation beyond this phase and make them sensitive to imatinib treatment by overexpressing immunoregulatory tyrosine activation motif (ITAM) with BCR-ABL in a Ph+ B-ALL mouse model. Ph+ B-ALL mouse models were induced by BCR-ABL using retroviral transduction/transplantation. Overexpression of ITAM promoted the differentiati
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