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toms persist, treatment with continuous step-down therapy should be applied.Introduction Concurrent opioid and benzodiazepine use ("double-threat" and double-threat and muscle relaxant use ("triple-threat" are postulated to increase morbidity versus opioids alone. Study objectives were to measure association between double- and triple-threat exposure and hospitalizations in a validated, nationally representative database of the United States. Methods A retrospective cohort study was conducted using the 2013 and 2014 Medical Expenditur
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