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The external validation of the model confirms good agreement between the predicted and experimental LogBB values for most of the compounds. The model enables the evaluation and optimization of the BBB permeability of potential neuroactive agents and other drug compounds.Biopotential sensing technology with electrodes has a great future in medical treatment and human-machine interface, whereas comfort and longevity are two significant problems during usage. Noncontact electrode is a promising alternative to achieve more comfortable and lo