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However, neutrophil-to-lymphocyte ratio significantly differed in relation to AICS (breast) grade (cut-off value, 1.7; p = 0.03, although only data from 72 patients were analyzed. To our knowledge, this is the first study to report associations of AICS (breast) grade with clinical variables. To our knowledge, this is the first study to report associations of AICS (breast) grade with clinical variables. Anorectal melanoma is a rare disease with a poor prognosis. Symptoms are often nonspecific, which complicates preoperative diagnosis