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023), elevated luteinizing hormone (LH) (OR = 1.085) and estradiol (E2; OR = 1.001) concentrations on the day of hCG administration (p less then 0.001 each). After omitting the protocol effect, the remaining factors showed limited contributions to highly elevated progesterone (ORs = 0.95-1.2). CONCLUSIONS The factor showing the greatest association with extreme progesterone elevation was use of the GnRH agonist protocol. BACKGROUND Low serum progesterone levels were strongly correlated with miscarriages in several publications and with