https://www.selleckchem.com/pr....oducts/hsp27-inhibit
The growing size of public variant repositories prompted us to test the accuracy of pathogenicity prediction of DNA variants using population data alone. Under the a priori assumption that the ratio of the prevalence of variants in healthy population vs that in affected populations form 2 distinct distributions (pathogenic and benign), we used a Bayesian method to assign probability to a variant belonging to either distribution. The approach, termed Bayesian prevalence ratio (BayPR), accurately parsed 300 of 313 expertly cura
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