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Three brand new sesquiterpenoids, chermesiterpenoids A-C (1-3), along with four known alkaloids (4-7), had been isolated and identified through the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of those brand-new sesquiterpenoids had been elucidated using detail by detail analysis associated with NMR data and their relative configurations had been elucidated utilizing atomic overhauser effect spectroscopy (NOESY) spectra in addition to gauge-independent atomic orbital (GIAO) NMR shift computations