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To ascertain the predictors of remission and relapse in patients of Cushing's disease (CD) undergoing pituitary transsphenoidal surgery (TSS). Patients with CD subjected to TSS over 35years at a tertiary care center were included. Patients were grouped into remission and persistent disease at 1year after surgery, and were further followed up for relapse. Demographic, clinical, biochemical, histological, radiological and post-operative follow-up parameters were analyzed. Of the 152 patients of CD, 145 underwent TSS. Remission was achieve