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We will put current practice in CAR-T cell therapy into the context of future challenges to be addressed in order for it to fulfil its "game-changing" therapeutic potential.The British Journal of Haematology has now been in existence for 65 years. In this time it has served the international community as well as British haematology and has become increasingly international in its outlook. Its changing content has mirrored the changes in haematology over more than six decades, particularly with an increasing emphasis on haematological neo