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Our results indicated that knockdown of linc00511 significantly inhibited TGF-β1-induced migration and invasion and down-regulated the mRNA and protein quantities of MMP2, MMP9 and MMP12 in TGF-β1 treated SPCA1 and H1975 cells. Additionally, western blotting results indicated that inhibition of linc00511 remarkably suppressed TGF-β1-induced N-cadherin, Vimentin and snail and enhanced E-cadherin phrase in SPCA1 and H1975 cells. Noteworthy, we further discovered that in