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Agreement on the perfect virtual cement space value for computer-aided design and computer-aided manufacturing (CAD-CAM) implant-supported resin-ceramic crowns with the best marginal adaptation is lacking. The range of cement gap settings in some CAD design software programs is wide (0 to 200 μm), and manufacturer recommendations regarding the best cement gap setting for certain types of ceramics is not specific. The purpose of this invitro study was to evaluate the effect of virtual cement gap settings on the marginal fit of cemented