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Epigenetic legislation plays a vital role in managing fungal secondary metabolism. Right here, we report the pleiotropic effects of the epigenetic regulator HdaA (histone deacetylase) on secondary metabolite production while the linked biosynthetic gene groups (BGCs) appearance within the plant endophytic fungus Penicillium chrysogenum Fes1701. Deletion of this hdaA gene in stress Fes1701 induced a substantial modification regarding the a