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Islet autoimmunity was diagnosed in 272 children. Colder air temperature during pregnancy was associated with developing islet autoimmunity at the address (per 2.2 °C decrease, Odds ratio (OR) 1.49; 95% Confidence interval (CI) 1.21-1.83) and zip-code level (per 2.4 °C decrease, OR 1.31; 95% CI 1.08-1.59). Using the addresses, significant associations were also observed during the first years of life. In this study, children's residential exposure to lower levels of air temperature during pregnancy and early life increased the risk of is
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