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In vitro researches had been performed to verify the immunohistochemical assessment. RESULTS 11βHSD1 immunoreactivity showed a substantial inverse correlation aided by the number of tumour-infiltrating lymphocytes and CD3- or CD8-positive T cells. 11βHSD1 immunoreactivity tended to be inversely correlated aided by the medical effectiveness for the IC blockade treatment. In vitro researches revealed that 11βHSD1 promoted the intratumoural synthesis of cortisol. This
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