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, and PODN were downregulated in both pancreatic tissues and cell lines. The present study showed that PDAC samples with high mRNAsi values exhibited aberrant activation of multiple metabolic pathways, and the patients from whom these samples were obtained had a poor prognosis. Future studies are expected to investigate the underlying mechanism based on the crosstalk between PDAC stemness and metabolic rewiring. The present study showed that PDAC samples with high mRNAsi values exhibited aberrant activation of multiple metabolic pathway
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