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ion. Direct-acting oral anticoagulants (DOACs) are increasingly used to prevent and treat thromboembolism. Although measurement of DOAC concentrations is not currently recommended as part of routine patient care, measurement of DOAC concentrations with anti-factor Xa activity assays have recently become clinically available. Our goal was to determine the clinical conditions under which DOAC concentration measurements are requested. Retrospective electronic medical record analysis of indications for DOAC concentration measurements by an