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The condensate flooding during dropwise condensation causes serious deterioration in heat transfer performance. In this study, the three-dimensional large-scale molecular dynamics simulation is carried out to investigate the droplet state transition from local flooding mode to Wenzel or from Wenzel to Cassie due to the droplet coalescence under the effect of nanostructure size. In particular, the effect of nanostructure breakage on droplet nucleation and growth is discussed to reveal the mechanism of dropwise condensation heat transfer d