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These results suggest that Prdx1 may be an effective therapeutic option to prevent DOX-induced cardiotoxicity. To determine the concentration of thiobarbituric acid reactive substances (TBARS) in erythrocytes and blood plasma, and the activities of selected antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in erythrocytes in patients receiving hyperbaric oxygen (HBO) treatment due to difficult-to-heal "skin wounds". . Indices of oxidative stress were assessed in venous blood taken from 23