https://www.selleckchem.com/products/GDC-0449.html
In mice, only treatments with holo-BLG prevented allergic sensitization and anaphylaxis, while sustaining regulatory T cells. BLG facilitated quercetin-dependent AhR-activation and, downstream AhR, lung Cyp1A1 expression. Holo-BLG shuttled iron into monocytic cells and impaired their antigen-presentation. Conclusion The cargo of holo-BLG is decisive in preventing allergy in vivo. BLG without cargo acted as allergen in vivo and further primed human mast cells for degranulation in an antigen-independent fashion. Our data provide mechanis
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