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Platelets expressed detectable levels of proBDNF (21±13 fmol/250x10 platelets). ProBDNF expression was mainly localized in the intracellular compartment. The proBDNF to BDNF molar ratio was ~15 in platelets and 101 in plasma. In stark contrast to the release of BDNF during platelet activation, intraplatelet and plasma concentrations of proBDNF remained stable following stimulation with classical platelet agonists, consistent with non-granular expression. Platelets express both the mature and the precursor form of BDNF. Whether the intr
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