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07% decrease of all-cause mortality. The pharmacological treatment reduced total-cholesterol (7.15mg/dl; 95%CI 1.46-12.85), LDL-cholesterol (5.06mg/dl; 95%CI 1.12-9.0, and triglycerides levels (9.88mg/dl; 95%CI 5.02-14.75), while it increased HDL-cholesterol (1.37mg/dl; 95%CI 0.17-2.57). Systolic blood pressure decreased (0.90mmHg; 95%CI 0.15-1.64). Although we were unable to demonstrate a superiority of anti-obesity medications over placebo on mortality, metaregression showed that even a small weight reduction tends to reduce all-cause