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Eventually, resveratrol surely could manifest its impact both by suppression of TNF-β-induced NF-κB and through direct activation associated with the Sirt1 and Runx2 path. Thus, through these researches, we provide a mechanism in which a T cell-derived cytokine, TNF-β make a difference bone formation through modulation of MSCs differentiation which involves NF-κB, Sirt1, Runx2 and resveratrol reversed TNF-β-promoted impairments in MSCs osteogenesis.Mammalian ferti
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