https://www.selleckchem.com/pr....oducts/tegatrabetan.
Furthermore, compounds 33i and 42f exhibited significant elevation in CASP8 levels. Compounds 33i and 42f inhibited VEGF. In addition, compound 42f showed significant decrease in levels of NF-κB p65. Moreover, apoptosis and cell cycle tests of the most active compound 42f, were performed. The results indicated that compound 42f significantly induce apoptosis in HCT-116 cells and arrest cell cycle at the G2/M phase.The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and sel
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