https://www.selleckchem.com/pr....oducts/Sunitinib-Mal
Blockade of the binding between Neonatal Fc receptor (FcRn) and IgG-Fc reduces circulating IgG, and thus emerges as a potential therapy for IgG-mediated autoimmune conditions. This was a double blind, randomized, single ascending dose study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of HBM9161 (a humanized FcR monoclonal antibody) in healthy Chinese volunteers. Subjects were randomized to receive a single SC dose of HBM9161 or placebo in a 31 ratio in three dosing cohorts (340 mg, 510 mg,
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