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During the 10-month follow-up after surgery, the limb functions of both patients improved significantly. This study demonstrates the safety and benefits of combined contralateral C7 to C7 and L5 to S1 cross nerve transfer for hemiplegic patients after stroke. This novel combined surgical approach could provide an optimal choice for patients suffering from both upper and lower limb dysfunction, to reduce hospital stay while reducing financial burden. This study demonstrates the safety and benefits of combined contralateral C7 to C7 and