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© The Author(s) 2020. For permissions, please e-mail journals.permissions@oup.com.The misfolding avoidance hypothesis postulates that series mutations give proteins cytotoxic and therefore the greater gene appearance the more powerful procedure of selection against substitutions. This results in prediction that general poisoning of extant proteins is greater for everyone evolving quicker. In our test, we picked pairs of fungus genetics which were paralogous but evolving at various prices.