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The correlation analysis of skin lipid alterations with the microbiome showed that Staphylococcus colonization in AD is positively correlated with ceramide subspecies AS, ADS, NS and NDS. This is the first study to reveal site-specific lipid alterations and correlations with the skin microbiome in AD. This is the first study to reveal site-specific lipid alterations and correlations with the skin microbiome in AD.Central action of the adipocyte hormone leptin via the neuropeptide Y (NPY) system is considered critical for energy homeosta