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13, 95% CI 1.02-1.23; = 0.012) were found to be significant independent risk parameters for recurrence. Sema4D is a novel biomarker that may help to identify individuals with recurrence after CA procedure in long term period in PAF. Sema4D is a novel biomarker that may help to identify individuals with recurrence after CA procedure in long term period in PAF.Introduction Cytochrome P450 (CYP) is a monooxygenase superfamily mediating the elimination of anti-hypertensive drugs. Polymorphisms of CYP would lead to differential drug efficacy.