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ther evidence for a reduction in frequency of surveillance echocardiography. Familial clustering of age at onset would have implications for both personalized screening and aetiology, but has not been studied for breast cancer. We prospectively studied a cohort of 23145 sisters to explore whether their breast cancer risk changed near the age at diagnosis of a previously affected older sister. Using an age-time-dependent variable in a Cox regression model, we estimated hazard ratios for breast cancer when participants were near their sister
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