https://www.selleckchem.com/products/GDC-0449.html
knockdown inhibited cell viability, proliferation, migration, and invasion, induced cell cycle arrest and promoted cell apoptosis in U138 and U251 cells. In U138/TMZ and U251/TMZ cell lines, upregulation enhanced TMZ resistance while downregulation reduced it. The knockdown of influenced the expressions of Notch pathway-related proteins. knockdown suppressed tumor growth and facilitated apoptosis in glioma mice model. affected glioma cell malignant behaviors and TMZ resistance via Notch signaling pathway and it might be a novel target
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