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In addition, wound surface temperature after wounding, and the application of CoolClot was recorded. There was no significant difference between the groups of study and control regarding the examined histopathologic parameters. The maximum increase in wound surface temperature was 1.56°C. One-time topical usage of CoolClot has no significant negative effect on the wound healing process. In addition, no significant increase in wound surface temperature will occur after the application of this agent. One-time topical usage of CoolClot ha
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