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In silico analysis detected 24 peptide sets with PD values lower than 10 between αs1- and β-CN, and 14 sets between αs1- and κ-CN. The amino acid sequences of αs1-CN (E61-E7 and β-CN (I12-E21) that showed the lowest PD value (5.3 were present in the characteristic sequence known as casein phosphopeptide (CPP). We detected strong cross-reactivity between CN components. Furthermore, we found highly homologous sequences in the CPP region, which contains a core sequence of "SSSEE" with phosphorylated serine residues. We detected strong cro