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In vivo application of siRNA formulation to SKH-1E hairless mice significantly suppressed Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) expression with no clinical evidence of toxicity. This strategy suggests a simple, personalized, and scalable platform for effective topical delivery of RNAi for treating genetic skin diseases. V.Cannabis is the most commonly used illicit drug among adolescents and young adults, including pregnant women. There is substantial evidence for a significant association between prenatal cannabis exposure