https://geldanamycininhibitor.....com/a-pilot-study-in
Targeted interruption of Paneth cellular lysozyme (Lyz1) protected mice from experimental colitis. Lyz1-deficiency diminished intestinal resistant reactions to bacterial molecular patterns and resulted in the growth of lysozyme-sensitive mucolytic micro-organisms, including Ruminococcus gnavus, a Crohn's disease-associated pathobiont. Ectopic lysozyme production in colonic epithelium suppressed lysozyme-sensitive bacteria and exacerbated colitis. Transfer of R. gnavus into L
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